Neurodevelopmental correlates in schizophrenia

Neurodevelopmental risk factors in schizophrenia.

The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigene...

Neurodevelopmental hypothesis of schizophrenia

The neurodevelopmental hypothesis of schizophrenia provided a valuable framework that allowed a condition that usually presents with frank disorder in adolescence or early adulthood to be understood at least in part as a consequence of events occurring early in development. However, the implications of the neurodevelopmental hypothesis for nosological conceptions of the disorder can only now be...

Neurodevelopmental rat models of schizophrenia

Animal models are very valuable for biomedical research. They enable to disclose pathological processes of the diseases and their treatment possibilities. Development of appropriate animal models of complex neuropsychiatric disorders, such as schizophrenia, is challenging since many clinical symptoms are difficult to replicate and assess in animals. There is strong evidence that disturbed brain...

Is schizophrenia a neurodevelopmental disorder?

Stereological analysis of cornu ammonis in prenatally stressed rats: a heuristic neurodevelopmental model of schizophrenia

Objective(s):The hippocampus has been implicated in pathophysiology of schizophrenia. Prenatal stress is a contributing risk factor for a wide variety of neuropsychiatric diseases including schizophrenia. This study examined long-term effects of prenatal restraint stress on the stereological parameters in the Cornu Ammonis (CA) of adult male rats as an animal model of schizophrenia. Materials ...